# EFFORT

![](https://1780686706-files.gitbook.io/~/files/v0/b/gitbook-legacy-files/o/assets%2F-McIh_3bbj8j0zl1VHdp%2F-Mg98dukKPf-mf-4N70-%2F-Mg98t-58Y0t_EidAwF9%2FEFFORT_logo.jpg?alt=media\&token=de0e25c0-dc54-4701-a13e-4783262d8385)

### PICO question

* *Population:* Mechanically ventilated ICU patients
* *Interventions:* ≥2.2 g/kg/day of protein (using dry pre-ICU actual body weight)
* *Comparison:* ≤1.2 g/kg/day of protein (using dry pre-ICU actual body weight)
* *Outcomes:* 60 day mortality, time to discharge

### Recruitment

| **Inclusion criteria**                                                                                                                                                                                                                                                                         | **Exclusion criteria**                                                                                                                                                                                   |
| ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- |
| <ul><li>≥18 years old</li><li>Likely to be mechanically ventilated >48h</li><li><p>At least one high risk feature:</p><ul><li>Low (<25) or High BMI (>35)</li><li>Moderate/severe malnutrition</li><li>Frailty </li><li>Sarcopenia</li><li>Likely to be ventilated >4 days</li></ul></li></ul> | <ul><li>>96 continuous hours of mechanical ventilation before enrolment</li><li>Expected death/withdrawal within 7 days</li><li>Pregnant</li><li>Needs TPN and no high-protein feeds available</li></ul> |

### Details

* Principle investigator: Dan Harvey
* Trainee-lead:&#x20;
* DREEAM: Cecilia Peters
* Website: <https://criticalcarenutrition.com/effort/about>
