ADAPT-Sepsis
Biomarker-guided duration of antibiotic treatment in hospitalised patients with suspected sepsis
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Biomarker-guided duration of antibiotic treatment in hospitalised patients with suspected sepsis
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Population: ICU patients who have started IV antibiotics for sepsis
Interventions: CRP or PCT guided recommendations regarding cessation of antibiotics
Comparison: Usual care
Outcomes: Duration of antibiotic use and 28-day mortality
Inclusion criteria
Exclusion criteria
≥18 years old
≤24 hours of empiric IV antibiotics** for suspected sepsis*
Likely to remain on IV antibiotics for >72 hours Requirement for critical care
>24 hours since first empiric IV antibiotics for suspicion of sepsis
>21 days antimicrobial therapy required (e.g. endocarditis, TB, osteomyelitis)
Severely immunocompromised (e.g. neutropenia not caused by sepsis)
All treatments for suspected sepsis likely to be stopped <24 hours for futility
Given, or anticipated to receive, an IL-6 receptor inhibitor
Consent declined
Previously enrolled in this trial.
Principle investigator: Dan Harvey
DREEAM: Julia Sampson
*Suspected sepsis definition: ‘acute organ dysfunction associated with suspected infection’ () **Note that this can include escalation of antibiotics - so someone who's been on co-amox on the ward for a CAP, and is being escalated to Tazocin for sepsis, might count
Trainee-lead:
Website:
