VITDALIZE
Effect of High-Dose Vitamin D3 on 28-Day Mortality in Adult Critically Ill Patients with Severe Vitamin D Deficiency
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Effect of High-Dose Vitamin D3 on 28-Day Mortality in Adult Critically Ill Patients with Severe Vitamin D Deficiency
Last updated
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Population: ICU patients with vitamin D deficiency (VDD)
Interventions: Vitamin D supplementation for 90 days
Comparison: Placebo
Outcomes: 28-day mortality
Inclusion criteria
Exclusion criteria
Patients ≥18 years
Anticipated ICU stay ≥48 hours
≤72 hours in ICU before screening for VDD
Severe VDD (≤12ng/ml ) after ICU admission
Severe GI dysfunction
Not expected to survive 48h / treatment withdrawal imminent
DNACPR
Hypercalcemia (>2.65mmol)
Kidney stones within the last 12 months
Active TB within the last 12 months
Sarcoidosis within the last 12 months
Pregnant/lactating
Hypersensitivity to the trial drug
Felt inappropirate by medical team
Prisoners
Principle investigator: Dan Harvey/Felix Fombon
Trainee-lead:
DREEAM: Lucy Morris
Website:
