VITDALIZE

Effect of High-Dose Vitamin D3 on 28-Day Mortality in Adult Critically Ill Patients with Severe Vitamin D Deficiency

PICO Question

• Population: ICU patients with vitamin D deficiency (VDD)

• Interventions: Vitamin D supplementation for 90 days

• Comparison: Placebo

• Outcomes: 28-day mortality

Recruitment

Inclusion criteria	Exclusion criteria
Patients ≥18 years Anticipated ICU stay ≥48 hours ≤72 hours in ICU before screening for VDD Severe VDD (≤12ng/ml ) after ICU admission	Severe GI dysfunction Not expected to survive 48h / treatment withdrawal imminent DNACPR Hypercalcemia (>2.65mmol) Kidney stones within the last 12 months Active TB within the last 12 months Sarcoidosis within the last 12 months Pregnant/lactating Hypersensitivity to the trial drug Felt inappropirate by medical team Prisoners

Details

• Principle investigator: Dan Harvey/Felix Fombon

• Trainee-lead:

• DREEAM: Lucy Morris

• Website: https://www.birmingham.ac.uk/research/bctu/trials/portfolio-v/vitdalize/index.aspx