GenOMICC

Genetics Of Mortality In Critical Care

Study question

  • Population: Critically unwell patients with specific illnesses

  • Comparison: Genomic sequencing

  • Outcomes:

    1. Identify genetic variants associated with susceptibility to, and mortality from, life-threatening infection and injury.

    2. Prioritise therapeutic targets to modulate the host response to injury and infection in patients with life-threatening disease.

Recruitment

Inclusion criteria

Exclusion criteria

  • Requiring continuous cardiovascular or respiratory monitoring or invasive mechanical ventilation

  • Provide appropriate consent or assent

  • Present with one of the following primary diagnoses:

    • Respiratory: COVID-19, Influenza, Pnuemonia, Secondary pneumonia, RSV, need for ECMO

    • ID: Cellulitis, Dengue, emerging infections*

    • Non-ID: Burns, pancreatitis, emerging critical illness syndromes**

  • Functionally limited by any comorbid illness

  • Significant immunosuppression

  • NOTE: Exclusion criteria don't apply to COVID-19

*"Emerging infections" means confirmed or suspected infection with a novel pathogen, a new strain of an existing pathogen, or a re-emerging known pathogen, that causes life-threatening illness e.g. MERS, SARS, new strains of influenza, Ebola or other viral haemorrhagic fevers, etc.

**"Emerging critical illness syndromes" are unexplained or idiosyncratic presentations of acute organ injury, or suspected reactions to therapeutic agents, e.g. acute disease associated with inhalation of noxious substances or vapours (such as "vaping") or acute disease associated with CAR T-cell therapy.

Details

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