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SOS

Sugar or Salt (SOS) trial: Hyperosmolar therapy in traumatic brain injury

PreviousSIGNET cascade trainingNextSTRESS-L

Last updated 3 years ago

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PICO Question

  • Population: Adult patients (aged >16 years) with severe TBI and raised intracranial pressure (ICP)

  • Interventions: 2ml/kg 20% mannitol intravenous bolus

  • Comparison: 2ml/kg bolus 2.7% hypertonic saline

  • Outcomes: Extended Glasgow Outcome Score at 6 months, ICP control, etc

Recruitment

Inclusion criteria

Exclusion criteria

  • Adult aged >16 years old

  • Admission following TBI

  • ICP >20mmHg for >5 mins (despite stage 1 management)

  • <10 days from initial primary head injury

  • Abnormal CT scan consistent with TBI

  • Devastating brain injury with withdrawal anticipated in <24h

  • Pregnancy

  • Severe hypernatraemia (>155 mmol/L)

Details

  • Principle investigator: Paul Candler

  • DREEAM: Julia Sampson

Trainee-lead:

Website:

https://warwick.ac.uk/fac/sci/med/research/ctu/trials/sos/
Available!