SOS

Sugar or Salt (SOS) trial: Hyperosmolar therapy in traumatic brain injury

PICO Question

• Population: Adult patients (aged >16 years) with severe TBI and raised intracranial pressure (ICP)

• Interventions: 2ml/kg 20% mannitol intravenous bolus

• Comparison: 2ml/kg bolus 2.7% hypertonic saline

• Outcomes: Extended Glasgow Outcome Score at 6 months, ICP control, etc

Recruitment

Inclusion criteria	Exclusion criteria
Adult aged >16 years old Admission following TBI ICP >20mmHg for >5 mins (despite stage 1 management) <10 days from initial primary head injury Abnormal CT scan consistent with TBI	Devastating brain injury with withdrawal anticipated in <24h Pregnancy Severe hypernatraemia (>155 mmol/L)

Details

• Principle investigator: Paul Candler

• Trainee-lead: Available!

• DREEAM: Julia Sampson

• Website: https://warwick.ac.uk/fac/sci/med/research/ctu/trials/sos/