STRESS-L

STudy into the REversal of Septic Shock with Landiolol (Beta Blockade)

PICO Question

• Population: ICU patients with septic shock on vasopressors

• Interventions: Landiolol (short acting beta blocker) infusion

• Comparison: Usual care

• Outcomes: Mean SOFA score

Recruitment

Inclusion criteria	Exclusion criteria
>18 years old Septic shock (according to Sepsis-3) Heart rate ≥95 bpm (24h after start of vasopressors) Receiving noradrenaline for ≥24h Noradrenaline dose ≥0.1mcg/kg/min	Noradrenaline dose <0.1 mcg/kg/min >72h after start of vasopressors Pre-existing severe cardiac dysfunction or untreated 2/3' heart block PMH: ischaemic stroke, TIA, or untreated severe carotid stenosis Pregnancy

Details

• Principle investigator: Dan Harvey

• Trainee-lead: Associate PI available!

• DREEAM: Lucy Ryan

• Website: https://stress-l.org/