STRESS-L

STudy into the REversal of Septic Shock with Landiolol (Beta Blockade)

PICO Question

  • Population: ICU patients with septic shock on vasopressors

  • Interventions: Landiolol (short acting beta blocker) infusion

  • Comparison: Usual care

  • Outcomes: Mean SOFA score

Recruitment

Inclusion criteria

Exclusion criteria

  • >18 years old

  • Septic shock (according to Sepsis-3)

  • Heart rate ≥95 bpm (24h after start of vasopressors)

  • Receiving noradrenaline for ≥24h

  • Noradrenaline dose ≥0.1mcg/kg/min

  • Noradrenaline dose <0.1 mcg/kg/min

  • >72h after start of vasopressors

  • Pre-existing severe cardiac dysfunction or untreated 2/3' heart block

  • PMH: ischaemic stroke, TIA, or untreated severe carotid stenosis

  • Pregnancy

Details

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