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  1. Currently recruiting

STRESS-L

STudy into the REversal of Septic Shock with Landiolol (Beta Blockade)

PreviousSOSNextTEAM

Last updated 3 years ago

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PICO Question

  • Population: ICU patients with septic shock on vasopressors

  • Interventions: Landiolol (short acting beta blocker) infusion

  • Comparison: Usual care

  • Outcomes: Mean SOFA score

Recruitment

Inclusion criteria

Exclusion criteria

  • >18 years old

  • Heart rate ≥95 bpm (24h after start of vasopressors)

  • Receiving noradrenaline for ≥24h

  • Noradrenaline dose ≥0.1mcg/kg/min

  • Noradrenaline dose <0.1 mcg/kg/min

  • >72h after start of vasopressors

  • Pre-existing severe cardiac dysfunction or untreated 2/3' heart block

  • PMH: ischaemic stroke, TIA, or untreated severe carotid stenosis

  • Pregnancy

Details

  • Principle investigator: Dan Harvey

  • DREEAM: Lucy Ryan

Septic shock (according to )

Trainee-lead:

Website:

https://stress-l.org/
Sepsis-3
Associate PI available!