EFFORT
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Population: Mechanically ventilated ICU patients
Interventions: ≥2.2 g/kg/day of protein (using dry pre-ICU actual body weight)
Comparison: ≤1.2 g/kg/day of protein (using dry pre-ICU actual body weight)
Outcomes: 60 day mortality, time to discharge
Inclusion criteria
Exclusion criteria
≥18 years old
Likely to be mechanically ventilated >48h
At least one high risk feature:
Low (<25) or High BMI (>35)
Moderate/severe malnutrition
Frailty
Sarcopenia
Likely to be ventilated >4 days
>96 continuous hours of mechanical ventilation before enrolment
Expected death/withdrawal within 7 days
Pregnant
Needs TPN and no high-protein feeds available
Principle investigator: Dan Harvey
Trainee-lead:
DREEAM: Cecilia Peters
Website:
