UK-ROX

Intensive Care Unit Randomised Trial Comparing Two Approaches to OXygen Therapy

PICO Question

• Population: ICU patients requiring mechanical ventilation with supplementary oxygen

• Interventions: Conservative oxygen therapy (SpO2 88-92%)

• Comparison: Usual care

• Outcomes: 90-day mortality

Recruitment

Inclusion criteria	Exclusion criteria
Aged ≥18 years Receiving IPPV following unplanned admission or IPPV started in ICU Receiving FiO2 >0.21	Previously in UK-ROX in the last 90 days Currently receiving ECMO One intervention arm specifically indicated/contraindicated

Details

• Principle investigator: Dan Harvey

• Trainee-lead:

• DREEAM: David Ford

• Website: https://www.icnarc.org/Our-Research/Studies/Uk-Rox

• FAQ section on website helpful in interpreting exclusion criteria (https://www.icnarc.org/Our-Research/Studies/Uk-Rox/Information-For-Sites/Faqs)