UK-ROX
Intensive Care Unit Randomised Trial Comparing Two Approaches to OXygen Therapy
PICO Question
Population: ICU patients requiring mechanical ventilation with supplementary oxygen
Interventions: Conservative oxygen therapy (SpO2 88-92%)
Comparison: Usual care
Outcomes: 90-day mortality
Recruitment
Inclusion criteria
Exclusion criteria
Aged ≥18 years
Receiving IPPV following unplanned admission or IPPV started in ICU
Receiving FiO2 >0.21
Previously in UK-ROX in the last 90 days
Currently receiving ECMO
One intervention arm specifically indicated/contraindicated
Details
Principle investigator: Dan Harvey
Trainee-lead:
DREEAM: David Ford
FAQ section on website helpful in interpreting exclusion criteria (https://www.icnarc.org/Our-Research/Studies/Uk-Rox/Information-For-Sites/Faqs)
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