SIGNET

Statins for Improving orGaN outcome in Transplantation

PICO Question

• Population: Patients confirmed dead using neurological criteria with potential to proceed to donation

• Interventions: Simvastatin 80 mg + protocolised standard care

• Comparison: Protocolised standard care

• Outcomes: Composite of death, cardiac mechanical circulatory support, or RRT within the first 30 days post- heart transplant

Recruitment

Inclusion criteria	Exclusion criteria
Confirmed dead using neurological criteria Consent for organ donation in place Within a recruiting Intensive Care unit	Aged under 18 Refusal of consent from donor family Planned donation after cessation of circulation (DCD) Known hypersensitivity to Simvastatin

Details

• Principle investigator: Dan Harvey

• Trainee-lead: Nick Plummer

• DREEAM: Treesa Joseph

• Website: https://www.nhsbt.nhs.uk/clinical-trials-unit/current-trials-and-studies/signet/