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  1. Currently recruiting

SIGNET

Statins for Improving orGaN outcome in Transplantation

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Last updated 3 years ago

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PICO Question

  • Population: Patients confirmed dead using neurological criteria with potential to proceed to donation

  • Interventions: Simvastatin 80 mg + protocolised standard care

  • Comparison: Protocolised standard care

  • Outcomes: Composite of death, cardiac mechanical circulatory support, or RRT within the first 30 days post- heart transplant

Recruitment

Inclusion criteria

Exclusion criteria

  • Consent for organ donation in place

  • Within a recruiting Intensive Care unit

  • Aged under 18

  • Refusal of consent from donor family

  • Planned donation after cessation of circulation (DCD)

  • Known hypersensitivity to Simvastatin

Details

  • Principle investigator: Dan Harvey

  • Trainee-lead: Nick Plummer

  • DREEAM: Treesa Joseph

Confirmed dead using

Website:

https://www.nhsbt.nhs.uk/clinical-trials-unit/current-trials-and-studies/signet/
neurological criteria